Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage.

  title={Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage.},
  author={Travis Jacob Klein and Barbara L. Schumacher and Megan E Blewis and Tannin A. Schmidt and Michael S Voegtline and Eugene J-Ma Thonar and Koichi Masuda and Robert L. Sah},
  journal={Tissue engineering},
  volume={12 6},
Articular cartilage provides a low-friction surface for joint articulation, with boundary lubrication facilitated by proteoglycan 4 (PRG4), which is secreted by chondrocytes of the superficial zone. Chondrocytes from different zones are phenotypically distinct, and their phenotypes in vitro are influenced by the system in which they are cultured. We hypothesized that culturing cells from the superficial (S) zone in two-dimensional monolayer or three-dimensional alginate would affect their… CONTINUE READING