Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

  title={Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies},
  author={Bryan Briney and Devin Sok and Joseph G. Jardine and Daniel W. Kulp and Patrick Skog and Sergey Menis and Ronald Jacak and Oleksandr Kalyuzhniy and Natalia de Val and Fabian Sesterhenn and Khoa Le and Alejandra G. Ramos and Meaghan J. Jones and Karen L Saye-Francisco and Tanya Blane and Skye Spencer and Erik Georgeson and Xiaozhen Hu and Gabriel Ozorowski and Yumiko Adachi and Michael Kubitz and Anita Sarkar and Ian A. Wilson and Andrew B. Ward and David Nemazee and Dennis R. Burton and William R. Schief},
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiate a bnAb response in animal models, but recall and maturation toward bnAb development has not been shown. Here, we report the development of boosting immunogens designed to guide… CONTINUE READING
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