• Corpus ID: 195061444

Tailor Made Phospholipid Based Curcumin Phytosomes: Fabrication, Characterization and Ex-Vivo Permeation

  title={Tailor Made Phospholipid Based Curcumin Phytosomes: Fabrication, Characterization and Ex-Vivo Permeation},
  author={Ahmed N Allam and Ibrahim A. Komeil and Ossama Y. Abdallah},
Curcumin (CUR), a highly lipophilic molecule has wide range of pharmacological activities. Nevertheless its limited aqueous solubility and extensive pre-systemic metabolism confine its bioavailability. CUR phytosomes were prepared by simple method and were evaluated in comparison to commercial patent product by DSC, FTIR, TEM, SEM as well as in vitro drug release profile in different dissolution media. Furthermore, a new ex-vivo experimental design utilizing non everted sac model was held out… 
4 Citations

Figures from this paper

Preparation and Evaluation of Curcumin Phytosomes by Rotary Evaporation Method

It is concluded that Curcumin phytosomes has better physical characteristics and improved permeability, solubility than that of curcumin drug to overcome the ability to cross lipid-rich biological membranes and which results in increase oral bioavailability.

Formulation and Optimization of In-Situ Buffered Formulation Containing Indomethacin In Combination With Pantoprazole

In-Situ buffer formulation contain agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. Here this approach is used

Evaluation of anti-diabetic activity of Syzygium cumini extract and its phytosome formulation against streptozotocin-induced diabetic rats

The Inner kernel of Syzygium cumini seeds were extracted and formulated in to a novel phytosome formulation by using cholesterol and lecithin with suitable method. The prepared Syzygium cumini seed

Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation

LPNs (99% drug loading) could be successfully tailored for DSN with improved dissolution and permeation characteristics, which is promising for lowering the influence of exogenous factors and increasing drug delivery.

Development and evaluation of novel microemulsion based oral formulations of 5-fluorouracil using non-everted rat intestine sac model

It is suggested that microemulsion formulation of 5-FU may be used for the treatment of human cancers after pharmacokinetic and clinical evaluation and in vivo pharmacodynamic studies suggest significant enhancement in the bioavailability and therapeutic efficacy.

A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity.

The RUB-solubilized CUR was stable in physiological conditions and did not precipitate when diluted or degrade when spray-dried to a completely reconstitutable powder and lays the foundation for future bioavailability improvement.

Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery.

Studies on solubility of curcumin

Curcumin is coming from the Curcuma longa which gives golden color and have the biological i mportance. As per the survey it is water insoluble, the poor solubili ty and wettability of curcumin leads

Characterization of curcumin-PVP solid dispersion obtained by spray drying.

Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems.

Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model.

  • B. WahlangY. PawarA. Bansal
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2011

Bioavailability enhancement of curcumin by complexation with phosphatidyl choline.

The results of ex vivo study show that CU-PC complex has significantly increased absorption compared with curcumin, when given in equimolar doses, and enhanced bioavailability and improved pharmacokinetics.

Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats.