Corpus ID: 195061444

Tailor Made Phospholipid Based Curcumin Phytosomes: Fabrication, Characterization and Ex-Vivo Permeation

  title={Tailor Made Phospholipid Based Curcumin Phytosomes: Fabrication, Characterization and Ex-Vivo Permeation},
  author={A. Allam and Ibrahim A. Komeil and O. Abdallah},
Curcumin (CUR), a highly lipophilic molecule has wide range of pharmacological activities. Nevertheless its limited aqueous solubility and extensive pre-systemic metabolism confine its bioavailability. CUR phytosomes were prepared by simple method and were evaluated in comparison to commercial patent product by DSC, FTIR, TEM, SEM as well as in vitro drug release profile in different dissolution media. Furthermore, a new ex-vivo experimental design utilizing non everted sac model was held out… Expand
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