Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.

@article{Nader2012TailanchoredMP,
  title={Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.},
  author={Moni Nader and Bart Westendorp and Omar Hawari and Maysoon Salih and Alexandre F. R. Stewart and Frans H H Leenen and Balwant S. Tuana},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 5},
  pages={H1138-45}
}
Sarcolemmal membrane-associated proteins (SLMAPs) are components of cardiac membranes involved in excitation-contraction (E-C) coupling. Here, we assessed the role of SLMAP in cardiac structure and function. We generated transgenic (Tg) mice with cardiac-restricted overexpression of SLMAP1 bearing the transmembrane domain 2 (TM2) to potentially interfere with endogenous SLMAP through homodimerization and subcellular targeting. Histological examination revealed vacuolated myocardium; the… CONTINUE READING