Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway

@inproceedings{Yagita2013TailanchoredPT,
  title={Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway},
  author={Yuichi Yagita and Takahide Hiromasa and Yukio Fujiki},
  booktitle={The Journal of cell biology},
  year={2013}
}
Tail-anchored (TA) proteins are anchored into cellular membranes by a single transmembrane domain (TMD) close to the C terminus. Although the targeting of TA proteins to peroxisomes is dependent on PEX19, the mechanistic details of PEX19-dependent targeting and the signal that directs TA proteins to peroxisomes have remained elusive, particularly in mammals. The present study shows that PEX19 formed a complex with the peroxisomal TA protein PEX26 in the cytosol and translocated it directly to… CONTINUE READING

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