Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes

  title={Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes},
  author={Marina Laplana and Manuel S{\'a}nchez-de-la-Torre and Alicia Aguil{\'o} and I. Casado and M Flores and Ramon S{\'a}nchez-Pellicer and Joan Fibla},
Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by modulating mineral homeostasis and key physiological processes such as cell proliferation and immune response. Vitamin-D insufficiency has been largely considered a risk factor for life-limiting illnesses including cardiovascular and immune-related diseases and cancer. Vitamin… 

Association of vitamin D receptor with longevity and healthy aging.

The data suggest that single nucleotide polymorphisms (SNPs) in FokI may be possibly involved in longevity and cognitive function.

Impact of vitamin D receptor polymorphisms in centenarians

A new scenario is proposed in which the variability of the VDR gene is relevant in the aging process and emphasizes the role of VDR genetic background in determining healthy aging.

Vitamin D receptor gene polymorphism and cardiovascular risk variables in elderly Polish subjects

There were no significant differences in anthropometric or biochemical parameters between genotypes in FokI in female and male groups, and the common allele B is connected with biochemical risk factors of CVD in older Caucasian men and women.

Distribution of eleven markers in South Romanian (Walachia region) population

The South Romanian population has not been well studied at the genetic level, so the frequency of allelic variants and genotypes in South Romanian areas situates in the range of values found with other Caucasian populations.



Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states

Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study.

This comprehensive candidate-gene analysis demonstrates that the risk allele of multiple VDR polymorphisms results in lower VDR mRNA levels, which could impact the vitamin D signaling efficiency and might contribute to the increased fracture risk the authors observed for these risk haplotype alleles.

Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users.

It is infer that VDR haplotypes might influence the risk of HIV-1 acquisition, and haplotypes for rs11568820, rs4516035, rs10735810, rs1544410, and rs17878969 polymorphisms showing association with protection to HIV- 1 infection are inferred.

Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis

Vitamin D in health and disease.

  • R. Heaney
  • Medicine
    Clinical journal of the American Society of Nephrology : CJASN
  • 2008
In patients with end-stage kidney disease, calcitriol and its analogs do not constitute adequate replacement in managing vitamin D needs of such patients, and the safest and most economical way to ensure adequate vitamin D status is to use oral dosing of native vitamin D.

Premature aging in vitamin D receptor mutant mice

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

It is intriguing that the possession of −1082G genotype, suggested to be associated with IL-10 high production, is significantly increased in centenarians, and points out that that gender is a major variable in the genetics of longevity, suggesting that men and women follow different strategies to reach longevity.

Vitamin D and aging: old concepts and new insights.

Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor.

For both the AR and VDR genes, the at-risk genotypes were more strongly associated with advanced disease than with localized disease, and both genes appear to preferentially confer risk for advanced disease.