Tagetone modulates the coupling of flunitrazepam and GABA binding sites at GABAA receptor from chick brain membranes.

@article{Perillo1999TagetoneMT,
  title={Tagetone modulates the coupling of flunitrazepam and GABA binding sites at GABAA receptor from chick brain membranes.},
  author={M. Perillo and D. Garc{\'i}a and R. Marin and J. Zygadlo},
  journal={Molecular membrane biology},
  year={1999},
  volume={16 2},
  pages={
          189-94
        }
}
  • M. Perillo, D. García, +1 author J. Zygadlo
  • Published 1999
  • Chemistry, Medicine
  • Molecular membrane biology
  • The effects of tagetone on flunitrazepam (FNTZ) binding to synaptosomal membranes from chick brains in the presence and absence of allosteric modulations induced by gamma-aminobutyric acid (GABA) were investigated. Tagetone, at 50 micrograms/ml (final concentration), decreased the binding affinity of [3H]FNTZ to synaptosomal membranes form chick brain (Kd = 3.34 +/- 0.36 nM without tagetone and Kd,t = 5.86 +/- 0.86 nM with tagetone; p < 0.05, two tailed Student's t-test) without affecting… CONTINUE READING
    20 Citations
    Effects of propofol and other GABAergic phenols on membrane molecular organization.
    • 29
    Surface activity of thymol: implications for an eventual pharmacological activity.
    • 84
    • PDF
    Stereo-selective activity of menthol on GABA(A) receptor.
    • 19

    References

    SHOWING 1-10 OF 20 REFERENCES
    Understanding the GABAA receptor: a chemically gated ion channel.
    • 218
    • PDF
    The benzodiazepines and their receptors: 25 years of progress
    • 71
    GABAA receptor subtypes: from pharmacology to molecular biology
    • D. Burt, G. L. Kamatchi
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 1991
    • 420