Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury.

@article{Liu2000TactileAI,
  title={Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury.},
  author={C. N. Liu and Patrick D. Wall and Efrat Ben-Dor and Martin 5 Michaelis and Ron Amir and Marshall Devor},
  journal={Pain},
  year={2000},
  volume={85 3},
  pages={503-21}
}
We examined the relation between ectopic afferent firing and tactile allodynia in the Chung model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four- to six-fold increase in the spontaneous ectopic discharge recorded in vivo in sensory axons in the ipsilateral L5 dorsal root (DR). The increase, which was not yet apparent 16 h postoperatively, was complete by 24 h. This indicates rapid modification of the electrical properties of the neurons. Only A-neurons… CONTINUE READING
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