Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial

  title={Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial},
  author={J. O'grady and A. Burroughs and P. Hardy and D. Elbourne and The Liver Transplant Group},
  journal={The Lancet},
  • J. O'grady, A. Burroughs, +2 authors The Liver Transplant Group
  • Published 2002
  • Medicine
  • The Lancet
  • BACKGROUND Calcineurin inhibitors are the most commonly used immunosuppressive drugs in liver transplantation, but the optimum initial immunosuppression regimen is not known. The aim of our study was to compare tacrolimus with microemulsified ciclosporin, in a regimen with standardised concomitant immunosuppressive therapy. METHODS In all liver transplant centres in the UK and Republic of Ireland, 606 patients undergoing a first orthotopic liver transplantation were randomly assigned open… CONTINUE READING
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