Tacrolimus strongly inhibits multiple human UDP-glucuronosyltransferase (UGT) isoforms.

Abstract

The objective of the present study is to clearly evaluate the inhibitory effects of tacrolimus (tacro) on important UGT isoforms in human liver, including determination of inhibition kinetic type and calculation of inhibition kinetic parameters. An in vitro incubation system was used to investigate the inhibitory effect of tacro on UGT isoforms. The… (More)

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@article{Liu2012TacrolimusSI, title={Tacrolimus strongly inhibits multiple human UDP-glucuronosyltransferase (UGT) isoforms.}, author={Xiaoyou Liu and Zhong-ze Fang and Pei-pei Dong and Xiang-hua Shi and Yan-Jie Teng and Xu-yong Sun}, journal={Die Pharmazie}, year={2012}, volume={67 9}, pages={804-8} }