Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis.

  title={Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis.},
  author={Eiji Ikeda and N Hikita and Kazuhiro Eto and Manabu Mochizuki},
  journal={Japanese journal of ophthalmology},
  volume={41 6},
Tacrolimus and rapamycin both belong to a new family of immunosuppressants, immunophilin ligands, but the mechanisms by which they inhibit T cell activation are different. Therefore, we tested the immunosuppressive effects of combination therapy with low doses of tacrolimus and rapamycin on experimental autoimmune uveoretinitis (EAU) in rats. Male Lewis rats, immunized with S-antigen (S-Ag) were given intraperitoneal injection of the combined drugs for 14 days after the immunization with S-Ag… CONTINUE READING


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Side effects of rapamycin in the rat.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 1995

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