Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children.

@article{Hofman2006TacrolimusOD,
  title={Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children.},
  author={Thilo Hofman and Noel Edward Cranswick and Piotr Kuna and Andrzej Boznański and Tadeusz Latoś and Milton Gold and D{\'e}d{\'e}e F Murrell and Kurt Gebauer and Ulrich Behre and Edyta Machura and Jonas Olafsson and Zsuzsanna Zs{\'o}fia Szalai},
  journal={Archives of disease in childhood},
  year={2006},
  volume={91 11},
  pages={905-10}
}
BACKGROUND Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression. AIMS In a 7-month, multicentre, randomised, controlled trial, we investigated the equivalence of response to vaccination against meningococcal serogroup C disease with a protein-conjugate vaccine in children (2-11 years) with moderate to severe atopic dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 121[corrected]) or a… CONTINUE READING

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