Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: formulation characterization and assessment of dermal delivery compared to referent ointment.

@article{Savi2019TacrolimusloadedLN,
  title={Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: formulation characterization and assessment of dermal delivery compared to referent ointment.},
  author={Vedrana Savi{\'c} and Tanja M Ili{\'c} and Ines Nikoli{\'c} and Bojan Markovi{\'c} and Bojan {\vC}alija and Nebojsa Cekic and Sne{\vz}ana Savi{\'c}},
  journal={International journal of pharmaceutics},
  year={2019},
  pages={
          118624
        }
}
Nanostructured lipid carriers (NLC) and nanoemulsions (NE) are colloid carriers which could improve dermal delivery of tacrolimus. The aims of this study were to evaluate effects of different formulation and process parameters on physicochemical characteristics and stability of lecithin-based NLC with glyceryl palmitostearate as solid and propylene glycol monocaprylate as liquid lipid and to compare the influence of different inner structure of tacrolimus-loaded NLC and corresponding NE on… 
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Nanocarriers Mediated Cutaneous Drug Delivery.
  • S. Güngör, E. Kahraman
  • Medicine
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2020
TLDR
The human structure and diseased skin barrier, and possible therapeutic outcomes of nanocarrier based drug delivery in the treatment of skin diseases due to their skin transport and follicular targeting mechanisms, are reviewed and a hope to provide targeting potential of the drugs into specific sites of the skin with minimizing side effects is offered.
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