Tacrolimus fails to regulate collagen expression in dermal fibroblasts.

Abstract

BACKGROUND The purpose of this study was to investigate the effects of tacrolimus on human fibroblasts derived from unwounded skin, hypertrophic scars (HTS), and keloids. We hypothesized that tacrolimus, a potent anti-inflammatory and immunosuppressant drug known to attenuate solid organ transplant fibrosis, would block collagen expression in human dermal… (More)
DOI: 10.1016/j.jss.2013.04.006

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