Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea.

@article{Jun2009TacrolimusCI,
  title={Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea.},
  author={Kyung Ran Jun and Woochang Lee and Mi Jang and Sail Chun and Gi-Won Song and Kwan Tae Park and Sung-Gyu Lee and Duck Jong Han and Changwon Kang and D H Cho and Jin Q. Kim and Won Ki Min},
  journal={Transplantation},
  year={2009},
  volume={87 8},
  pages={1225-31}
}
BACKGROUND Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus, the most commonly used immunosuppressive agent in organ transplant recipients. We have determined the genotypic frequencies of the CYP3A and ATP-binding cassette sub-family B member 1 (ABCB1) genes, which encode the CYP3A and P-gp proteins, respectively, in Korean organ transplant recipients and donors, and have assessed the influence of CYP3A and ABCB1 polymorphisms on… CONTINUE READING
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