Tacrolimus and sirolimus induce reproductive abnormalities in female rats.

@article{Shivaswamy2011TacrolimusAS,
  title={Tacrolimus and sirolimus induce reproductive abnormalities in female rats.},
  author={Vijay Shivaswamy and Luann Ochsner and Dulce M Maroni and Cheng Wang and Joel Z Passer and Cara E. Clure and Frederick G. Hamel and John S. Davis and Jennifer Larsen},
  journal={Transplantation},
  year={2011},
  volume={91 12},
  pages={1333-9}
}
BACKGROUND Immunosuppression medications contribute to posttransplant diabetes mellitus in patients and can cause insulin resistance in male rats. Tacrolimus (TAC)-sirolimus (SIR) immunosuppression is also associated with appearance of ovarian cysts in transplant patients. Because insulin resistance is observed in patients with polycystic ovary syndrome, we hypothesized that TAC or SIR may induce reproductive abnormalities. METHODS We monitored estrus cycles of adult female rats treated daily… CONTINUE READING