Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.

@article{Larsen2006TacrolimusAS,
  title={Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.},
  author={Jennifer Lynne Larsen and Robert G. Bennett and Tab W. Burkman and Ana Lisa Ramirez and Sakura Yamamoto and James M Gulizia and Stanley J. Radio and Frederick G. Hamel},
  journal={Transplantation},
  year={2006},
  volume={82 4},
  pages={466-70}
}
BACKGROUND Tacrolimus-sirolimus immunosuppression has improved islet graft survival but may affect islet function. METHODS We studied the effects of tacrolimus, sirolimus, or both in normal adult male Sprague Dawley rats. Glucose and insulin response to oral glucose load and pancreas pathology were evaluated after two weeks of daily tacrolimus (1-8 mg/kg/day), sirolimus (0.08-8 mg/kg/day), or low-dose sirolimus (0.08 mg/kg/day) plus tacrolimus (1 mg/kg/day) treatment compared to controls… CONTINUE READING

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