Tacrolimus Population Pharmacokinetic-Pharmacogenetic Analysis and Bayesian Estimation in Renal Transplant Recipients

@article{Benkali2009TacrolimusPP,
  title={Tacrolimus Population Pharmacokinetic-Pharmacogenetic Analysis and Bayesian Estimation in Renal Transplant Recipients},
  author={K. Benkali and A. Pr{\'e}maud and N. Picard and Jean-Philippe R{\'e}rolle and O. Toupance and G. Hoizey and A. Turcant and F. Villemain and Y. Meur and P. Marquet and A. Rousseau},
  journal={Clinical Pharmacokinetics},
  year={2009},
  volume={48},
  pages={805-816}
}
  • K. Benkali, A. Prémaud, +8 authors A. Rousseau
  • Published 2009
  • Medicine
  • Clinical Pharmacokinetics
  • AbstractObjectives: The aims of this study were (i) to investigate the population pharmacokinetics of tacrolimus in renal transplant recipients, including the influence of biological and pharmacogenetic covariates; and (ii) to develop a Bayesian estimator able to reliably estimate the individual pharmacokinetic parameters and inter-dose area under the blood concentration-time curve (AUC) from 0 to 12 hours (AUC12) in renal transplant patients. Methods: Full pharmacokinetic profiles were… CONTINUE READING
    116 Citations
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