Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea

@article{Jun2009TacrolimusCI,
  title={Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea},
  author={K. Jun and W. Lee and M. Jang and S. Chun and G. Song and K. Park and S. Lee and D. Han and C. Kang and D. Cho and J. Kim and Won-Ki Min},
  journal={Transplantation},
  year={2009},
  volume={87},
  pages={1225-1231}
}
  • K. Jun, W. Lee, +9 authors Won-Ki Min
  • Published 2009
  • Medicine
  • Transplantation
  • Background. Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus, the most commonly used immunosuppressive agent in organ transplant recipients. We have determined the genotypic frequencies of the CYP3A and ATP-binding cassette sub-family B member 1 (ABCB1) genes, which encode the CYP3A and P-gp proteins, respectively, in Korean organ transplant recipients and donors, and have assessed the influence of CYP3A and ABCB1 polymorphisms… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 25 REFERENCES
    An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients.
    • 166
    Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • 1,935
    • PDF
    The genetic determinants of the CYP3A5 polymorphism.
    • 629