Tackling the threat of antimicrobial resistance: from policy to sustainable action

@article{Shallcross2015TacklingTT,
  title={Tackling the threat of antimicrobial resistance: from policy to sustainable action},
  author={Laura J. Shallcross and Simon Howard and Tom A Fowler and Sally C. Davies},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2015},
  volume={370}
}
  • L. Shallcross, S. Howard, S. Davies
  • Published 5 June 2015
  • Medicine, Political Science
  • Philosophical Transactions of the Royal Society B: Biological Sciences
Antibiotics underpin all of modern medicine, from routine major surgery through to caesarean sections and modern cancer therapies. These drugs have revolutionized how we practice medicine, but we are in a constant evolutionary battle to evade microbial resistance and this has become a major global public health problem. We have overused and misused these essential medicines both in the human and animal health sectors and this threatens the effectiveness of antimicrobials for future generations… 

Figures from this paper

Antimicrobial Stewardship: Fighting Antimicrobial Resistance and Protecting Global Public Health

This review highlights AMR’s scale and consequences, the importance, and implications of an antimicrobial stewardship program (ASP) to fight resistance and protect global health.

Non-antibiotic pharmaceutical agents as antibiotic adjuvants

The issue of antibiotic resistance in the 21st century is a three-sided problem: i) the emerge of drugresistant mutants against newly developed antibiotics is an inevitable evolutionary process, while the non-prudent use of antibiotics only exacerbates this process; ii) the costs of clinical research and the development of novel antibiotics – coupled with the relatively modest returns on investment from these drugs – lead to a shift in the interest of pharmaceutical companies to instead develop drugs for chronic illnesses.

Measuring and mapping the global burden of antimicrobial resistance

The inclusion of mortality and morbidity data related to drug-resistant infections into the annual Global Burden of Disease Study should help fill the evidence base to drive forward research and policy agendas to combat AMR.

Much more is expected from nations to counter antimicrobial resistance: World Health Organization

It is very important to understand that antibiotic resistance has spread to the entire world, and is jeopardizing the act of treating common infections in both community and healthcare establishment settings.

Future antibacterial strategies: from basic concepts to clinical challenges.

Ongoing investigations extend large scale microbiome analyses to new natural sources, target the host-pathogen interface, include nanotechnologies and rejuvenate old paths, such as phages and bacteriocins, which should help to improve future prevention and treatment of MDR bacterial infections.

The evolving response to antibiotic resistance (1945–2018)

The evolving response to antibiotic resistance is traced through what at this point appear to be five eras, with antibiotic resistance still more palpably and publicly embedded within larger concerns over global emerging infections, social justice, and development goals, attracting interest from a diverse cohort of actors.

The Concept of an Ideal Antibiotic: Implications for Drug Design

The aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and the specific attributes of an ideal antibacterial drug.

Antibiotics in the clinical pipeline at the end of 2015

There is growing global recognition that the continued emergence of multidrug-resistant bacteria poses a serious threat to human health. Action plans released by the World Health Organization and

How promising are combinatorial drug strategies in combating Candida albicans biofilms?

In this Editorial, it is proposed that, in addition to screening for novel antibiofilm or antipersister compounds, combination therapy might be a valid alternative to existing antimicrobial therapy.

Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries

A narrative review of ongoing activities across sectors was undertaken to improve antimicrobial use and address issues with vaccines including COVID-19 and it is imperative to develop new quality indicators for ambulatory care given current concerns.
...

References

SHOWING 1-10 OF 23 REFERENCES

A new antibiotic kills pathogens without detectable resistance

The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.

Assessing the impact of national antibiotic campaigns in Europe

Evidence is found that public campaigns significantly reduce the use of antimicrobials in the community by 1.3–5.6 defined daily doses per 1,000 inhabitants yearly, which represents an impact of roughly 6.5–28.3 % on the mean level of antibiotic use in Europe between 1997 and 2007.

Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing

Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing revealed its origin and probable modes of transmission, and revealed the weaknesses in this medical who-done-it, informing improvements in hospital preventive measures.

Challenges of Antibacterial Discovery

  • L. Silver
  • Biology
    Clinical Microbiology Reviews
  • 2011
The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort.

Mandatory surveillance of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in England: the first 10 years.

The enhanced mandatory surveillance scheme in England has captured a wealth of data that have helped to further define the epidemiology of MRSA bacteraemia and it is to be hoped that based on the English experience of mandatory surveillance, other countries will consider the implementation of similar schemes.

The European Antibiotic Awareness Day.

The European Antibiotic Awareness Day will be an annually recurring event that will raise awareness about the risks associated with inappropriate use of antibiotics and how to use antibiotics responsibly.

Penicillin. Nobel Lecture

  • http://www. nobelprize.org/nobel_prizes/medicine/laureates/1945/ fleming-lecture.pdf (accessed
  • 2015