Tackling the diversity of triple-negative breast cancer.

  title={Tackling the diversity of triple-negative breast cancer.},
  author={Nicholas C. Turner and Jorge S Reis-Filho},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 23},
Triple-negative breast cancer (TNBC) comprises a highly diverse collection of cancers. Here, we review this diversity both in terms of gene expression subtypes and the repertoire of genetic events. Transcriptomic analyses of TNBC have revealed at least six subtypes, with the luminal androgen receptor (luminal AR) or molecular apocrine cancers forming a distinct group within triple-negative disease. Distinct from the gene expression subtypes, a diverse set of genetic events have been described… CONTINUE READING
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