Tackling the cancer signal transduction “labyrinth”: a combinatorial use of biochemical tools with mathematical models will enhance the identification of optimal targets for each molecular defect.

@article{Karamouzis2014TacklingTC,
  title={Tackling the cancer signal transduction “labyrinth”: a combinatorial use of biochemical tools with mathematical models will enhance the identification of optimal targets for each molecular defect.},
  author={Michalis V Karamouzis and Athanasios G. Papavassiliou},
  journal={Cancer},
  year={2014},
  volume={120 3},
  pages={316-22}
}
Unraveling cancer-associated molecular defects is crucial for further pharmacological targeting. Although novel techniques are being developed to elucidate genomic, proteomic, and transcriptomic alterations, the map of protein interactions and aberrations in normal but also in malignant cells is still obscure. It has been recently shown that many of the… CONTINUE READING