Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

@article{Shih2015TacklingTC,
  title={Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities},
  author={Shou-Ping Shih and Man-Gang Lee and Mohamed El‐Shazly and Yung-Shun Juan and Zhi-Hong Wen and Ying-Chi Du and Jui Hsin Su and Ping-Jyun Sung and Yu-Cheng Chen and Juan-Cheng Yang and Yang-Chang Wu and Mei-Chin Lu},
  journal={Marine Drugs},
  year={2015},
  volume={13},
  pages={3132 - 3153}
}
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against leukemia Molt 4 cells. Accumulating evidence showed that HQ may act as a potent protein kinase inhibitor in cancer therapy. To fully understand the mechanism of HQ, we further explored the precise molecular targets in leukemia Molt 4… 

Figures from this paper

The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90
TLDR
The findings indicated that xestoquinone targeted leukemia cancer cells through multiple pathways, suggesting its potential application as an antileukemic drug lead.
Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress
TLDR
The cytotoxic effect of isoaaptamine is associated with the induction of apoptosis and autophagy through oxidative stress and represents an interesting drug lead in the war against breast cancer.
Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90
TLDR
The results suggested that the proapoptotic effect of the isolates is mediated through the inhibition of Hsp90 and topoisomerase activities, and the molecular docking analysis suggested that 1 exhibited more binding affinity to N-terminal ATP-binding pocket of HSp90 protein than 17-AAG, a standard Hsp 90 inhibitor.
Synthesis and antitumor evaluation of hybrids of 5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates and carbohydrates.
TLDR
The most promising compound, derived from isoquinoline-5,8-dione, containing ribofuranosidyl ring, was selectively active in vitro against H1299 cancer cells, with 1.7-fold higher activity than that of vinorelbine tartrate, suggesting that the glycoconjugate in question may constitute a valuable lead compound to design and synthesize a more active and less toxic derivative with respect to the development of a new antitumor substance.
Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge
TLDR
The multiple targets of EEAC on breast cancer cells suggested that this extract may be developed as a potential dietary supplement targeting this debilitating disease.
MARINE NATURAL PRODUCTS WITH HIGH ANTICANCER ACTIVITIES.
TLDR
This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities and places an emphasis on several drugs originating from marine natural Products that have already been marketed or are currently in clinical trials.
Role of Natural Products in Modulating Histone Deacetylases in Cancer
TLDR
The potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors is emphasized.
A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors
TLDR
This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities.
Encouraging Leads from Marine Sources for Cancer Therapy A Review Approach
Cancer has been one of the major causes of mortality and morbidity globally and is expected to rise about 70 % over the next two decades.1It is estimated that over 8.8million people are dying of
Histone Deacetylase Inhibitors | Encyclopedia
TLDR
A large number of HDACs are involved in cancerassociated cell hyperproliferation, invasion, and metastasis, and these enzymes ay also act on non-histone proteins, thereby influencing many fundamental cellular processes, including microtubule dynamics and intracellular transport, metabolism, and aging.
...
...

References

SHOWING 1-10 OF 43 REFERENCES
Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction
TLDR
10AB-induced apoptosis is mediated through the overproduction of ROS and the disruption of mitochondrial metabolism, suggesting that ROS overproduction plays a crucial rule in the cytotoxic activity of 10AB.
Mitochondria: a promising target for anticancer alkaloids.
TLDR
This review describes mitochondria as a central component in the anticancer action of a set of alkaloids, in a way to illustrate the importance of this organelle in medicinal chemistry.
Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.
  • Ying-Chi Du, F. Chang, M. Lu
  • Biology, Chemistry
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2012
Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drug.
TLDR
The present review focuses on the cellular/ molecular aspects involved in resistance of tumor cells to camptothecins, including the potential role of cancer stem cells and deregulated miRNAs, and on the approaches proposed for overcoming resistance.
Novel Relationship between the Antifungal Activity and Cytotoxicity of Marine-Derived Metabolite Xestoquinone and Its Family
TLDR
The cytotoxicity against two human squamous cell carcinoma cell lines indicated that the terminal quinone structure of the polycyclic molecules was important (xestoquinone, etc).
Mitochondria as a Target in the Therapeutic Properties of Curcumin
TLDR
Some of the most recent findings of curcumin properties that suggest a close relationship of this antioxidant with the mitochondrial function are focused on.
...
...