Tackling the Challenges of Clinical Trials in Palliative Care

@article{Currow2012TacklingTC,
  title={Tackling the Challenges of Clinical Trials in Palliative Care},
  author={David Christopher Currow and Meera R. Agar and Amy P. Abernethy},
  journal={Pharmaceutical Medicine},
  year={2012},
  volume={25},
  pages={7-15}
}
There is an ethical imperative to provide the best quality of care for all people, including people at the end of life. In order to provide such care, each intervention used in clinical practice must be tested objectively for net clinical benefit (response and toxicity). For pharmacological and non-pharmacological interventions, the gold standard of evidence remains a phase III randomized, controlled study. In palliative care, there is a gradually emerging evidence base for clinical practice… 

Outcome measures for palliative care research

  • M. AgarT. Luckett
  • Medicine, Psychology
    Current opinion in supportive and palliative care
  • 2012
The current state of the science in physical symptoms and other end-of-life care domains and/or illness-specific outcomes in palliative care is summarized to allow consolidation of outcome measurement and the ability to extend measurement from the clinical trial setting into routine clinical practice.

Attitudes of Palliative Care Practitioners Towards Enrolling Patients in Clinical Trials

Comparing results of the current study and those findings of more than a decade earlier revealed that attitudes have either not substantially changed or in some areas have become less accepting of clinical trials, despite the dramatic increase in the volume of research carried out within palliative care over the last decade.

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This study validates the use of the phase II feasibility study to assess protocol viability in a palliative population prior to embarking on a larger trial.

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This review provides up-to-date evidence on key challenges and ethical considerations about researching with end-of-life patients and important recommendations for clinicians, research, and ethics committee members when evaluating clinical research with people at their end of life.

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A scientific review of representative studies recognizing how clinical hypnosis in medicine is an effective complementary therapy, for pain and symptom's relief in severe chronic diseases and in palliative care is reviewed.

Gaps in the evidence base of opioids for refractory breathlessness. A future work plan?

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