Tackling frontal lobe–related functions in PKU through functional brain imaging: a Stroop task in adult patients

@article{Sundermann2011TacklingFL,
  title={Tackling frontal lobe–related functions in PKU through functional brain imaging: a Stroop task in adult patients},
  author={Benedikt Sundermann and Bettina Pfleiderer and Harald E. M{\"o}ller and Wolfram Schwindt and Josef Weglage and J{\"o}ran Lepsien and R Feldmann},
  journal={Journal of Inherited Metabolic Disease},
  year={2011},
  volume={34},
  pages={711-721}
}
Profound mental retardation in phenylketonuria (PKU) can be prevented by a low phenylalanine (Phe) diet. However, even patients treated early have inconsistently shown deficits in several frontal lobe–related neuropsychological tasks such as the widely accepted Stroop task. The goal of this study was to investigate whether adult patients exhibit altered brain activation in Stroop-related locations in comparison to healthy controls and if an acute increase in blood Phe levels in patients has an… CONTINUE READING
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