Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities.

@article{Kietadisorn2012TacklingED,
  title={Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities.},
  author={Rinrada Kietadisorn and Rio P. Juni and An L Moens},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={302 5},
  pages={E481-95}
}
Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of endothelial function. The bioavailability of eNOS-derived NO is crucial for this function and might be affected at multiple levels. Uncoupling of eNOS, with subsequently less NO and more superoxide generation, is one of the major underlying causes of endothelial dysfunction found in atherosclerosis, diabetes… CONTINUE READING
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