Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer.

@article{Kenny2007TacklingES,
  title={Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer.},
  author={Paraic A. Kenny},
  journal={Expert opinion on therapeutic targets},
  year={2007},
  volume={11 10},
  pages={1287-98}
}
TNF-alpha converting enzyme (TACE/ADAM17) is a transmembrane metalloprotease that plays a key role in the cleavage and mobilization of receptor ligands that are initially synthesized as membrane-tethered precursors. For many years, attention has focused on the role of TACE-dependent TNF-alpha cleavage in arthritis and, more recently, it has become apparent that TACE also plays an important role in regulating epidermal growth factor receptor activity in several tumor types. This review presents… CONTINUE READING