Tachyphylactic properties of angiotensin II analogs with bulky and hydrophobic substituents at the N-terminus.

Abstract

Tachyphylaxis, defined as the acute loss of response of some smooth muscles upon repeated stimulations with angiotensin II (Ang II), has been shown to be dependent mainly on the N-terminal region of the ligand. To further study the structural requirements for the induction of tachyphylaxis we have synthesized Ang II analogs containing the bulky and very… (More)

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