Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.

@article{Tattersall1996TachykininNR,
  title={Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.},
  author={Frederick D Tattersall and Wayne Rycroft and Bahaa Francis and David Pearce and Kalpana Merchant and Angus M Macleod and Tammy Ladduwahetty and Linda E. Keown and Christopher J. Swain and R Robin Baker and Margaret A. Cascieri and Elliot M Ber and Joseph M Metzger and D Euan Macintyre and R. R. Hill and Richard J. Hargreaves},
  journal={Neuropharmacology},
  year={1996},
  volume={35 8},
  pages={1121-9}
}
These studies have compared the pharmacological profile of two non-peptide human type neurokinin1 (hNK1) receptor selective antagonists, L-741,671 and a quaternised compound L-743,310. In radioligand binding studies L-741,671 and L-743,310 had high affinity for ferret and cloned hNK1 receptors [Ki (nM) ferret 0.7 and 0.1; human 0.03 and 0.06, respectively] but low affinity for rodent NK1 receptors [Ki (nM) 64 and 17, respectively] suggesting that ferret receptors have hNK1-like binding… CONTINUE READING
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