Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G(q)-dependent pathway.

@article{Williams2007Tachykinin1RS,
  title={Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G(q)-dependent pathway.},
  author={Ronald Williams and Xiaoyan Zou and Gary W. Hoyle},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 2},
  pages={L430-7}
}
The respiratory tract is innervated by irritant-responsive sensory nerves, which, on stimulation, release tachykinin neuropeptides in the lung. Tachykinins modulate inflammatory responses to injury by binding to tachykinin (neurokinin) receptors present on various pulmonary cell types. In the present study, the activation of the proinflammatory transcription factor NF-kappaB in lung epithelial cells was investigated as a mechanism by which tachykinins stimulate inflammatory processes. In A549… CONTINUE READING
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