Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction.

@article{Selby2011TachycardiainducedDD,
  title={Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction.},
  author={Donald E. Selby and Bradley M. Palmer and Martin Lewinter and Markus Meyer},
  journal={Journal of the American College of Cardiology},
  year={2011},
  volume={58 2},
  pages={147-54}
}
OBJECTIVES The purpose of this study is to evaluate tachycardia-induced relaxation abnormalities in myocardium from patients with a normal ejection fraction. BACKGROUND Diastolic dysfunction and left ventricular (LV) hypertrophy are closely linked. Tachycardia can induce heart failure symptoms in otherwise asymptomatic patients. To study the effects of tachycardia on myocardial contractility and relaxation, we evaluated the effects of increasing pacing rates in myocardial biopsy samples… CONTINUE READING