Tachycardia-induced change of atrial refractory period in humans: rate dependency and effects of antiarrhythmic drugs.

BACKGROUND Atrial fibrillation (AF) has been shown to shorten the atrial effective refractory period (ERP) and make the atrium more vulnerable to AF. This study investigated the effect of atrial rate and antiarrhythmic drugs on ERP shortening induced by tachycardia. METHODS AND RESULTS Seventy adult patients without structural heart disease were included… (More)