Tachycardia in spontaneously hypertensive and normotensive rats after fusaric acid and bupicamide

@article{Antonaccio1976TachycardiaIS,
  title={Tachycardia in spontaneously hypertensive and normotensive rats after fusaric acid and bupicamide},
  author={Michael J. Antonaccio and D T Cot{\'e} and Thomas A. Cavaliere},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={1976},
  volume={3}
}
1. The effects of the dopamine‐β‐hydroxylase inhibitors bupicamide, fusaric acid, FLA‐63 and U‐14,624 on blood pressure and heart rate of spontaneously hypertensive rats were examined. 
11 Citations
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References

SHOWING 1-10 OF 26 REFERENCES
Biological Sciences: Adrenal Tyrosine Hydroxylase and Dopamine β-Hydroxylase in Spontaneously Hypertensive Rats
SPONTANEOUSLY hypertensive (SH) rats, a Wistar strain1, are extremely useful for screening antihypertensive agents which inhibit the biosynthesis of catecholamine hormones. We describe here aExpand
Blood Pressure Decreased by Halobutylpicolinic Acid, an Inhibitor of Dopamine β-Hydroxylase
TLDR
Disulphiram, through its reduced metabolite diethyldithiocarbamate (DDC), is an effective inhibitor of dopamine β-hydroxylase3,4 and had been used successfully in the treatment of hypertension in man until 5-butylpicolinic acid was tried. Expand
The clinical trial of a new hypotensive agent, "fusaric acid (5-butylpicolinic acid)": the preliminary report.
TLDR
This study proved the hypotensive activity of this compound in humans, for the purpose of testing whether or not this compound could be a unique antihypertensive drug in clinical medicine. Expand
SCH 10595, an effective dopamine- -hydroxylase inhibitor and a hypotensive agent.
TLDR
The compound was found to lower blood pressure effectively in deoxycorticosterone acetate-hypertensive rats over a wide range of doses (30-300 mg/kg) and the blood pressure-lowering effect was well correlated with the reduction of endogenous NE levels in sympathetically innervated tissues. Expand
Pharmacology of fusaric acid in man
TLDR
It is suggested that the degree of plasma DBH inhibition by fusaric acid may be used for estimates of fusoric acid blood levels. Expand
INHIBITION OF DOPAMINE β-HYDROXYLASE BY AROMATIC AND ALKYL THIOUREAS
Severall aromatic and alkyl thioureas were effective inhibitors of a purified bovine adrenal dopamine β-hydroxylase preparation. Inhibition of the enzyme by U-10,157 (1,Expand
On the significance of central noradrenaline for motor activity: experiments with a new dopamine beta-hydroxylase inhibitor.
TLDR
The results are compatible with the view that the inhibition of motility caused by FLA-63 is due to inhibition of noradrenaline synthesis, and the parameters measured were within normal limits. Expand
In vivo inhibition of dopamine beta-hydroxylase by 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624).
TLDR
Inhibition of dopamine β-hydroxylase by U-14,624 results in a specific depletion of norepinephrine (NE) in both mouse brain and rat brain and the effectiveness of the block in the synthesis of endogenous NE was demonstrated by the accumulation of DA resulting from loading rats with L-dopa and monoamine oxidase inhibition. Expand
Effects of chronic pretreatment with pargyline upon responses of the atrial pacemaker and of left atrial strips of guinea pigs to tyramine, mephentermine, d-amphetamine and adrenergic nerve stimulation.
TLDR
It is indicated that the chronic administration of pargyline has a bretylium-like effect upon adrenergic neurons and this results do not support the suggestion of Kopin et al. (1965) that after administration of monoamine oxidase inhibitors norepinephrine storage sites accumulate substances which serve as false transmitters of lesser potency than nore Pinephrine. Expand
Disposition of SCH 10595 in animals and man.
TLDR
The absorption, metabolism and excretion of isotopically (14C) labeled Sch 10595 \[5-( n -butyl)-picolinamide\] (I) were studied in the rat and compared with observations made in man, dog and monkey, finding a complex pattern of urinary metabolites was found. Expand
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