Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.

  title={Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.},
  author={Tina L. Tinley and Deborah A. Randall-Hlubek and Rachel M. Leal and Evelyn M. Jackson and James W. Cessac and James C. Quada and Thomas K. Hemscheidt and Susan L. Mooberry},
  journal={Cancer research},
  volume={63 12},
During the course of a mechanism-based screening program designed to identify new microtubule-disrupting agents from natural products, we identified a crude extract from Tacca chantrieri that initiated Taxol-like microtubule bundling. Bioassay-directed purification of the extract yielded the highly oxygenated steroids taccalonolides E and A. The taccalonolides caused an increased density of cellular microtubules in interphase cells and the formation of thick bundles of microtubules similar to… CONTINUE READING


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