Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.

@article{Tinley2003TaccalonolidesEA,
  title={Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.},
  author={Tina L. Tinley and Deborah A. Randall-Hlubek and Rachel M. Leal and Evelyn M. Jackson and James W. Cessac and James C. Quada and Thomas K. Hemscheidt and Susan L. Mooberry},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={3211-20}
}
During the course of a mechanism-based screening program designed to identify new microtubule-disrupting agents from natural products, we identified a crude extract from Tacca chantrieri that initiated Taxol-like microtubule bundling. Bioassay-directed purification of the extract yielded the highly oxygenated steroids taccalonolides E and A. The taccalonolides caused an increased density of cellular microtubules in interphase cells and the formation of thick bundles of microtubules similar to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin

Cancer Chemotherapy and Pharmacology • 2007
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 1997
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…