Tacalcitol and narrow‐band phototherapy in patients with vitiligo

@article{Leone2006TacalcitolAN,
  title={Tacalcitol and narrow‐band phototherapy in patients with vitiligo},
  author={G Leone and Alessia Pacifico and Paolo Iacovelli and Andrea Paro Vidolin and Mauro Picardo},
  journal={Clinical and Experimental Dermatology},
  year={2006},
  volume={31}
}
Background.  Vitiligo is a skin disease characterized by loss of normal pigmentation in the skin. Several treatments exist but none is really effective. Recently, perturbations of calcium homeostasis in vitiliginous epidermis have been described. 
Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta‐analysis
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Phototherapy especially narrow‐band UV‐B (NBUVB) has been considered as mainstay of therapy in nonsegmental vitiligo (generalized type). Topical tacalcitol has also been claimed to be effective,
Does topical tacrolimus ointment enhance the efficacy of narrowband ultraviolet B therapy in vitiligo? A left–right comparison study
  • I. Majid
  • Medicine
    Photodermatology, photoimmunology & photomedicine
  • 2010
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The aim of combining topical agents is to improve the efficacy of NB‐UVB in causing repigmentation in vitiligo.
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TLDR
Narrow-band UVB (NB-UVB 310-315 nm) radiation is now considered as the "gold standard" for the treatment of diffuse vitiligo.
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TLDR
Treatment options such as Narrowband Ultraviolet B (NB-UVB), Targeted Phototherapy, and Excimer laser on the medical front, in addition to epidermal cell transplantation and melanocyte culture transplants on the surgical front, have all revolutionized the management of this psychologically devastating disease.
Vitiligo Management: An Update
TLDR
Treatment options such as Narrowband Ultraviolet B (NB-UVB), Targeted Phototherapy, and Excimer laser on the medical front, in addition to epidermal cell transplantation and melanocyte culture transplants on the surgical front, have all revolutionized the management of this psychologically devastating disease.
Vitiligo therapy
Vitiligo can be treated using various new and experimental therapies, such as narrow-band ultraviolet B microphototherapy (NB-UVB), narrow-band ultraviolet B excimer laser and monochromatic excimer
Randomized, double‐blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo
TLDR
Tacalcitol and other vitamin D analogues have been shown to have stimulating activity both on immunomodulatory mediators and on melanocytes in lesional skin.
Photo(chemo)therapy for vitiligo
TLDR
NB UVB (310–315 nm) radiation is now considered as the ‘gold standard’ for the treatment of diffuse vitiligo, and treatment with two recently introduced UVB sources that emit 308’nm wavelengths, the 308‰nm xenon chloride (XeCl) excimer laser and the 307‽nm XeCl excimer light, has also been reported to be effective.
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