Tacalcitol, an Active Vitamin D3, Induces Nerve Growth Factor Production in Human Epidermal Keratinocytes

@article{Fukuoka2001TacalcitolAA,
  title={Tacalcitol, an Active Vitamin D3, Induces Nerve Growth Factor Production in Human Epidermal Keratinocytes},
  author={Masamichi Fukuoka and Katsutoshi Sakurai and Tomohiro Ohta and Mamoru Kiyoki and Ichiro Katayama},
  journal={Skin Pharmacology and Physiology},
  year={2001},
  volume={14},
  pages={226 - 233}
}
The human epidermal keratinocyte cell line K-TL-1, developed from a benign epidermal tumor, was cultured in the presence of the synthetic vitamin D3 analogue tacalcitol [1α,24(R)-dihydroxyvitamin D3] to assess the effects on the production of nerve growth factor (NGF). Confluent K-TL-1 cells were cultured with 10–8M of tacalcitol. Supernatants and cell homogenates were collected and NGF concentrations were determined by enzyme-linked immunosorbent assay. The concentration of NGF in the… 

Figures from this paper

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System
TLDR
A greater role for calcitriol may be envisioned in the peripheral nervous system, as it is involved in myelination, axonal homogeneity of peripheral nerves, and neuronal-cell differentiation.
ANTINOCICEPTIVE EFFECT OF 1,25 DIHYDROXY VITAMIN D3 IN A NEUROPATHIC PAIN MODEL
TLDR
The results suggest that 1,25 dihydroxy vitamin D3 does not affect the pain threshold in normal animals but reduces abnormal pain in the rat model of neuropathy and administration of Vitamin D in clinic may provide new approach for treatment of chronic pain.
Up-regulation of vitamin D system in adipocytes by macrophage-derived factors: implications for (patho)physiology of adipose tissue
TLDR
Vitamin D deficiency is suggested to contribute to the pathogenesis of various diseases including certain types of cancer, inflammatory bowel disease, multiple sclerosis, periodontal diseases, diabetes, hypertension, atherosclerosis and neurodegenerative diseases.
Vitamin D as a Neuroactive Substance: Review
TLDR
More research is needed on vitamin D because it may play a role as a relatively safe and inexpensive pharmaceutical in the prevention and treatment of a number of common neuropsychiatric conditions.
Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction.
TLDR
Vitamin D supplementation can improve glucose tolerance and cardiovascular autonomic function and can thus reduce cardiovascular mortality among subjects with different stages of glucose intolerance and autonomic dysfunction, however, more patient-centered trials on the use of vitamin D supplementation in different conditions are needed.
Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes
TLDR
Darier's disease and Hailey–Hailey disease are skin disorders arising from autosomal dominant mutations in ATP2A2 and ATP2C1, encoding the Golgi apparatus calcium ATPase, and exposure to ultraviolet (UV) B irradiation exacerbates the skin lesions.
Le Hericium erinaceus: des propriétés essentiellement dépendantes du neuronal growth factor
TLDR
Hericium erinaceus induces the synthesis of neuronal growth factor (NGF), implicated in neuro-degenerative diseases such as Alzheimer dementia or more generally in atrophic diseases (stomac, intestinal mucosa, liver) or fibroblasts, chondrocytes or osteoblasts stimulation.
Vitamin D for the treatment of painful diabetic neuropathy
TLDR
Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic Neuropathy.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Production of Interleukin 1 Alpha by a Trichilemmoma Cell Line
TLDR
A trichilemmoma cell line, KTL‐1, was found to produce ETAF satisfactorily in its culture supernatant, and Messenger RNA expression was easily detected in K TL‐1 cells stimulated by lipopolysaccharide (LPS).
1,25-Dihydroxyvitamin D3 Induction of Nerve Growth Factor in L929 Mouse Fibroblasts: Effect of Vitamin D Receptor Regulation and Potency of Vitamin D3 Analogs1.
TLDR
The VDR in L929 cells is characterized and it is shown that 1,25-(OH)2D3 and its less calcemic analogs induce NGF, and up-regulation of VDR abundance enhanced NGF induction.
Immunocytochemical localization of the 1,25-dihydroxyvitamin D3 receptor in target cells.
TLDR
The studies demonstrate the feasibility of the immunocytochemical approach to visualize the 1,25-dihydroxyvitamin D3 receptor in target tissues and show that it is predominantly a nuclear protein in the relatively unoccupied and fully activated states.
Effect of 1,24R‐dihydroxyvitamin D3 on the Growth of Human Keratinocytes
TLDR
It is demonstrated that 1,24R(OH)2D3 functions as a potent growth inhibitor in vitro in human keratinocytes from both normal and psoriatic epidermis, and it possesses a higher affinity for the 1,25(OH).
An AP-1 site in the nerve growth factor promoter is essential for 1, 25-dihydroxyvitamin D3-mediated nerve growth factor expression in osteoblasts.
TLDR
Data show that in osteoblasts, 1,25(OH)2D3 induces NGF expression indirectly by increasing AP-1 binding activity, demonstrating that this AP- 1 site is essential for 1, 25(OH), 2D3-mediated NGF up-regulation.
1 , 25-Dihydroxyvitamin D 3 Induction of Nerve Growth Factor in L 929 Mouse Fibroblasts : Effect of Vitamin D Receptor Regulation and Potency of Vitamin D 3 Analogs *
TLDR
The VDR in L929 cells is characterized and it is shown that 1,25-(OH)2D3 and its less calcemic analogs induce NGF induction, which has significance for the eventual treatment of neurodegenerative diseases that are caused by decreased NGF production.
1,24(R)‐Dihydroxyvitamin D3, a Novel Active Form of Vitamin D3 with High Activity for Inducing Epidermal Differentiation but Decreased Hypercalcemic Activity
TLDR
The incubation of mouse epidermal keratinocytes with 1,24(OH)2D3 induced their differentiation in a time‐ and dose‐dependent manner, as determined by the formation of a cornified envelope and an increase in the activity of transglutaminase.
...
1
2
3
4
5
...