Tabletting of pellet-matrix systems: ability of parameters from dynamic and kinetic models to elucidate the densification of matrix formers and of pellets.

@article{Kuehl2002TablettingOP,
  title={Tabletting of pellet-matrix systems: ability of parameters from dynamic and kinetic models to elucidate the densification of matrix formers and of pellets.},
  author={Peter Kuehl and Jobst B. Mielck},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={248 1-2},
  pages={101-14}
}
Two different types of pellets, i.e. drug-free sugar spheres, and pellets, spray-layered with crystalline theophylline and coated with Eudragit RS/RL, were tabletted each in combination with matrix-forming powder mixtures of Avicel PH200 and PEG 4000. The die fills from pellets and powder mixtures were regarded as two-compartment systems with a volume… CONTINUE READING