Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats.

  title={Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats.},
  author={Siriporn C Chattipakorn and Anucha Pongpanparadorn and Wasana Pratchayasakul and Anchalee Pongchaidacha and Kornkanok Ingkaninan and Nipon Chattipakorn},
  journal={Journal of ethnopharmacology},
  volume={110 1},
The current pharmacotherapy for Alzheimer's disease (AD) is the use of acetylcholinesterase inhibitors (AChE-Is). A previous in vitro study showed that Tabernaemontana divaricata extract (TDE) can inhibit AChE activity. However, neither the AChE inhibitory effects nor the effect on neuronal activity of TDE has been investigated in vivo. To determine those effects of TDE in animal models, the Ellman's colorimetric method was implemented to investigate the cortical and circulating cholinesterase… CONTINUE READING


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