Tabby pattern genetics – a whole new breed of cat

  title={Tabby pattern genetics – a whole new breed of cat},
  author={Christopher B. Kaelin and Gregory S. Barsh},
  journal={Pigment Cell \& Melanoma Research},
  • C. Kaelin, G. Barsh
  • Published 1 August 2010
  • Biology, Medicine
  • Pigment Cell & Melanoma Research
Much of what we know about pigment cell biology comes from studying laboratory mice, yet the conservation of gene action and interaction across domesticated animals, including horses, cattle, pigs, and dogs, is firm evidence that most aspects of color variation are conserved in mammals. [...] Key Method The nomenclature has become complicated; similar to Eizirik et al. (2010), we use lower case roman to describe theExpand
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus)
Bioinformatic and molecular modeling analysis suggests that changes in the Ticked locus disrupt a key disulfide bond in the Dkk4 cysteine‐rich domain 1 or DKK4 signal peptide cleavage respectively. Expand
Genetics of pigmentation in dogs and cats.
A molecular genetic review of pigmentary variation in dogs and cats is presented using a nomenclature and logical framework established by early leaders in the field to provide insight into areas that transcend pigment cell biology. Expand
Developmental Genetics of Color Pattern Establishment in Cats
The results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identity new targets for diverse pattern variation in other mammals. Expand
Developmental genetics of color pattern establishment in cats
The results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identify targets for diverse pattern variation in other mammals. Expand
How the Leopard Hides Its Spots: ASIP Mutations and Melanism in Wild Cats
The occurrence of melanism (darkening of the background coloration) is documented in 13 felid species, in some cases reaching high frequencies at the population level. Recent analyses have indicatedExpand
Genetic Architecture of Skewed X Inactivation in the Laboratory Mouse
It is concluded that Xcea is either a derived allele that arose concurrently with the domestication of fancy mice but prior the derivation of most classical inbred strains or a rare allele in the wild, and that each mouse taxa examined has a different functional Xce allele. Expand
Who’s behind that mask and cape? The Asian leopard cat’s Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed
The compound heterozygote state suggests the leopard cat allele, in combination with the recessive non-agouti allele, influences Bengal markings, producing a darker, yet not completely melanistic coat. Expand
Behavioral associations with breed, coat type, and eye color in single-breed cats
In this study, behavioral characteristics in purebred cats were hypothesized to associate with breed, eye color, coat color, and coat pattern. Owners of 574 single-breed, registered cats completedExpand
Marcadores Genéticos del Color para Determinar la Estructura Genética de Gatos Domésticos (Felis catus) en Zonas Rurales de Lorica, Colombia
La estructura genetica de gatos domesticos (Felis catus) en ambientes rurales de Lorica, Colombia fue analizada, utilizando marcadores morfologicos del color y se encontro diferencias entre poblaciones y poco flujo genetico entre ellas. Expand


Defining and Mapping Mammalian Coat Pattern Genes: Multiple Genomic Regions Implicated in Domestic Cat Stripes and Spots
It is hypothesized that mammalian patterned coats are formed by two distinct processes: a spatially oriented developmental mechanism that lays down a species-specific pattern of skin cell differentiation and a pigmentation-oriented mechanism that uses information from the preestablished pattern to regulate the synthesis of melanin profiles. Expand
A study of variation in Singapore cats
The purpose of this paper is to find out to what extent there are regional differences in gene fiequencies and in quantitative characters in cat populations in different parts of the world, and what light these facts throw on the evolution of the domestic cat and on evolutionary phenomena in general. Expand
Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat.
It is concluded that amber colour in NFCs is caused by a single MC1R allele called e, which has never been documented. Expand
A model for generating aspects of zebra and other mammalian coat patterns.
  • J. Bard
  • Biology, Medicine
  • Journal of theoretical biology
  • 1981
Analysis of a spotted zebra in the light of the model provides evidence that zebra stripes arise from the inhibition rather than the stimulation of melanin; their pattern is thus of white stripes on a black background. Expand
Gene frequencies in London's cats
  • A. Searle
  • Biology, Medicine
  • Journal of Genetics
  • 2008
The hypothesis of random mating was tested by using the results for yellow and tortoiseshell, and was found satisfactory, andGene frequencies were estimated on this hypothesis, and a significant tendency for male castration to increase hair length. Expand
Comparative genetics of coat colour in mammals.
  • 1959
Inheritance of coat‐color in cats