• Corpus ID: 6680748

TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.

@article{Nagatsu1964TYROSINEHT,
  title={TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.},
  author={Toshiharu Nagatsu and Miriam Levitt and Sidney Udenfriend},
  journal={The Journal of biological chemistry},
  year={1964},
  volume={239},
  pages={
          2910-7
        }
}
After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of norepinephrine shown in Fig. 1 was proposed. Although evidence for this pathway was well established by isot,opic procedures (2, 3), it was not until 1960 that Levin, Levenberg, and Kaufman (4) succeeded in isolating and characterizing the third enzyme in the series, dopamine-B-oxidase (@hydroxylase). The enzyme responsible for converting tyrosine to dopa has… 
Activity of adrenal catecholamine-producing enzymes and their regulation after stress.
The pathway for biosynthesis of catecholamines from tyrosine was first proposed by Blaschko in 1939 (3), but only recently have separate enzymatic reactions been characterized. Conversion of tyrosine
Enzymes Involved in the Catalysis of Catecholamine Biosynthesis
TLDR
The postulated biosynthetic pathway for the formation of the adrenergic transmitters was the subject of several studies and was confirmed with the use of radioactive labeled precursors.
The Role of Tyrosine Hydroxylase in the Regulation of Catecholamine Synthesis
TLDR
Biopterin, the putative natural pterin cosubstrate, was first demonstrated in adrenal medulla cells (Lloyd and Weiner 1971) and is also present in brain tissue and the concentration of tetrahydrobiopterin in various brain regions is correlated with the distribution of catecholamines.
Enzymes Controlling the Biosynthesis of Catecholamines
TLDR
It is now possible to investigate the activities of these enzymes in tumors such as neuroblastoma and pheochromocytoma, and to determine which of those enzymes is responsible for the overproduction of catecholamines.
Regional distribution of tyrosine hydroxylase in rat brain 1
TLDR
The regional distribution of tyrosine hydroxylase in the rat brain is examined and the results suggest that the distribution of this enzyme in the brain is concentrated in the amygdala and hippocampus.
Enzymes of Synthesis and Degradation of Catecholamines and 5-Hydroxytryptamine
TLDR
There is evidence that certain functions of the central nervous system are regulated by these biogenic amines, such as the state of consciousness, vasomotor control, and thermoregulation, as well as the range of physiologic roles of catecholamines.
Biosynthesis of Noradrenaline in Sympathetic Nervous Tissue
TLDR
This paper shows that the complete synthetic mechanism is present in nerve terminals, and that significant amounts of noradrenaline may be synthesized at these terminals.
Tyrosine Hydroxylase: Biochemical Properties and Short-term Regulation in vitro and in vivo
TLDR
The physiological importance of TH has been evidenced by recent studies showing that targeted disruption of the TH gene results in mid-gestational lethality: about 90% of mutant embryos die between embryonic days 11.5 and 15.5, apparently of cardiovascular failure.
...
...

References

hp://w w w .jb.org/ D ow nladed from Toshiharu Nagatsu, Morton Levitt and Sidney Udenfriend BIOSYNTHESIS Tyrosine Hydroxylase: THE INITIAL STEP IN NOREPINEPHRINE
  • Anal. Biochem.,
  • 1955