TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

@article{Jin2011TXNIPPR,
  title={TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1},
  author={H Jin and S Seo and Y S Kim and S-H Woo and K Y Lee and J Yi and S B Lee and T-B Choe and Jeong-hoon Lee and Songzhu Michael An and S-I Hong and I-C Park},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={3792-3801}
}
The mammalian target of rapamycin (mTOR) is a highly conserved serine–threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediating dissociation of 14-3-3 from tuberous sclerosis complex (TSC)2, which allows formation of a TSC–TSC2 complex. In the present study, we identify TXNIP that inhibits mTOR activity… CONTINUE READING
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