TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo

@article{Xue2015TXA9AC,
  title={TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo
},
  author={Rui Xue and Na Han and Mingyu Xia and Chun Ye and Zhihui Hao and Li-hui Wang and Yu Wang and Jingyu Yang and Ikuo Saiki and Jun Yin},
  journal={Steroids},
  year={2015},
  volume={94},
  pages={51-59}
}

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References

SHOWING 1-10 OF 29 REFERENCES
Induction of apoptosis in Lewis lung carcinoma cells by an intestinal bacterial metabolite produced from orally administered ginseng protopanaxadiol saponins.
The present study demonstrated that oral administration of an intestinal bacterial metabolite(M1) of protopanaxadio1-type saponin significantly inhibited the tumor growth at the implantation site
Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas.
TLDR
Results revealed that these compounds possessed potential antitumor activities, and the characteristic morphological changes in PC-9 cells treated with cardenolides indicated cell inhibition due to apoptosis.
alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases.
TLDR
It is shown that AFP cytotoxicity is closely related to apoptosis, as shown by cell morphology, nuclear DNA fragmentation and caspase-3-like activity resulting in cleavage of poly(ADP-ribose) polymerase.
The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas.
TLDR
Glioblastoma patients who do not respond to chemotherapy and whose tumors over-express NaK alpha1 subunits could benefit from a treatment using ligands with marked binding affinity for the NaKalpha1 subunit.
Novel therapeutic applications of cardiac glycosides
TLDR
The increased susceptibility of cancer cells to these compounds supports their potential use as cancer therapies, and the first generation of glycoside-based anticancer drugs are currently in clinical trials.
Cytotoxic Cardenolides from Streptocaulon griffithii
TLDR
A new cardenolide, 3‐O‐(β‐glucopyranosyl)acovenosigenin A (1), was isolated from the roots of Streptocaulon griffithii and found to be strongly cytotoxic against other human tumor cell lines, including A549, MCF‐7, and Hela cells.
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
TLDR
Understanding the molecular events that regulate apoptosis in response to anticancer chemotherapy, and how cancer cells evade apoptotic death, provides novel opportunities for a more rational approach to develop molecular-targeted therapies for combating cancer.
...
...