TX-1877: design, synthesis, and biological activities as a BRM-functional hypoxic cell radiosensitizer.

  title={TX-1877: design, synthesis, and biological activities as a BRM-functional hypoxic cell radiosensitizer.},
  author={S. Kasai and H. Nagasawa and H. Kuwasaka and T. Oshodani and A. Nishioka and Y. Ogawa and S. Yoshida and S. Inayama and T. Inomata and H. Hori},
  journal={International journal of radiation oncology, biology, physics},
  volume={42 4},
PURPOSE 2-Nitroimidazole acetamide TX-1877 and its derivatives (TX-1877 analogs) were designed, synthesized, and evaluated by their in vitro and in vivo radiosensitization, tumor growth control, suppression of lung metastasis, and immunopotentiation, as biological response modifier (BRM)-functional hypoxic cell radiosensitizers. MATERIALS AND METHODS TX-1877 analogs were designed and synthesized in our laboratory. In vitro radiosensitizing ability was estimated using EMT6/KU cells under… Expand
8 Citations
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