TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells.

@article{Weiss2012TWIST1IA,
  title={TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells.},
  author={Michele B. Weiss and Ethan V Abel and Melanie M. Mayberry and Kevin J. Basile and Adam C Berger and Andrew E. Aplin},
  journal={Cancer research},
  year={2012},
  volume={72 24},
  pages={6382-92}
}
Tumor cells often use developmental processes to progress toward advanced disease. The E-box transcription factor TWIST1 is essential to epithelial-mesenchymal transition (EMT) and cell migration in the developing neural crest. In melanoma, which derives from the neural crest cell lineage, enhanced TWIST1 expression has been linked to worse clinical prognosis. However, mechanisms underlying TWIST1 expression and whether aberrant TWIST1 levels promote steps in melanoma progression remain unknown… CONTINUE READING

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