TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma.

  title={TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma.},
  author={Abdelkader Selmi and Maud de Saint-Jean and Anne-Catherine Jallas and Elisabeth Garin and Michael D. Hogarty and Jean B{\'e}nard and Alain Puisieux and Aur{\'e}lien Marabelle and Sandrine Valsesia-Wittmann},
  journal={Cancer letters},
  volume={357 1},
In neuroblastoma, MYCN amplification is associated with a worse prognosis and is a criterion used in the clinic to provide intensive treatments to children even with localized disease. In correlation with MYCN amplification, upregulation of TWIST1, a transcription factor playing a crucial role in inhibition of apoptosis and differentiation, was previously reported. Clinical data set analysis of MYCN, MYC and TWIST1 expression permits us to confirm that TWIST1 expression is upregulated in MYCN… CONTINUE READING
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