TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer

@article{Okada2010TWIST1HI,
  title={TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer},
  author={Toshiyuki Okada and Yutaka Suehiro and Koji Ueno and Shoko Mitomori and Sayaka Kaneko and Mitsuaki Nishioka and Naoko Okayama and Kouhei Sakai and Shingo Higaki and Shoichi Hazama and Hiroshi Hirata and Isao Sakaida and Masaaki Oka and Yuji Hinoda},
  journal={Genes},
  year={2010},
  volume={49}
}
Although growing evidence demonstrates that TWIST1 is an interesting tumor biomarker, little is known about the clinical significance of TWIST1 expression and TWIST1 methylation in human primary colorectal cancer. In this study, we examined the association of TWIST1 expression and TWIST1 methylation with clinicopathologic features in human primary colorectal tumors. Primary colorectal cancer (CRC) specimens from 319 patients, corresponding normal colorectal nontumorous mucosa from 251 patients… 
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TWIST1 hypermethylation is observed in pancreatic cancer.
TLDR
The results suggested that TWIST1 methylation is a useful biomarker for the screening of pancreatic cancers and studies using independent data sets are required to confirm these findings.
TWIST1 Is Expressed in Colorectal Carcinomas and Predicts Patient Survival
TLDR
Results suggest that TWIST1 expression levels could be a tumor indicator in stage II patients and help select patients at greater risk of poor prognosis who might benefit from adjuvant chemotherapy.
Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
  • Ho-Jin Kang, E. Kim, +4 authors Y. Hong
  • Biology, Medicine
    Journal of preventive medicine and public health = Yebang Uihakhoe chi
  • 2012
TLDR
Evidence is provided for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.
TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
TLDR
A possible epigenetic link between TWIST proteins and the tumor budding phenotype is investigated and hypermethylation of the tumor stroma may represent an alternative mechanism for regulation of TWIST1.
Methylated genes in breast cancer
TLDR
Several novel, positive associations are reported between percent methylation of the APC, RASSF1A, TWIST, ERα, CDH1, and Cyclin D2 genes and key variables such as tumor stage, hormone and growth receptor status, and a history of recurrent or metastatic disease.
Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype.
Methylation in Colorectal Cancer
TLDR
The aim has been to define the molecular profiles including patterns of hypermethylation of the most important cancer candidate genes, polymorphism and mutation of specific genes in CRC in studies, with relatively different environmental and genetic factors compared to Western countries.
Hypermethylation of TWIST1 and NID2 in tumor tissues and voided urine in urinary bladder cancer patients.
TLDR
The combined methylation analysis of TWIST1 and NID2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine in bladder cancer patients.
High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes
TLDR
The biological associations suggest an involvement of the tumor microenvironment in TWIST1's adverse role in breast cancer, an independent prognostic factor for poor prognosis in LNN/ER-positive breast cancer.
DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells
TLDR
The studies suggested that the Twist1 transcription in GC cells might be regulated through potential cooperation of DNA methylation, histone modification in complex with Sp1 binding to CpG-rich regions within the exon 1 region.
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References

SHOWING 1-10 OF 53 REFERENCES
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TLDR
It is found that TWist1 promoter methylation is significantly more prevalent in malignant compared with healthy breast tissue and the percentage of cells expressing TWIST1 was greater in breast malignancy compared with matched healthy tissue from the same patients.
TWIST1 Overexpression is Associated with Nodal Invasion and Male Sex in Primary Colorectal Cancer
TLDR
Evidence for upregulation of TWIST1 mRNA in colorectal cancer is provided, suggesting its implication in the onset of malignant progression of this disease.
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer.
TLDR
Data indicate that BRCA1-associated breast cancers show less promoter methylation compared with sporadic breast carcinomas indicating a difference in disease etiology.
Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis
TLDR
The results suggest that upregulation of Twist plays a role in the neoplastic transformation to oesophageal SCC and subsequent development of distant metastasis and may serve as a useful prognostic marker for predicting the development of remote metastasis in oes Sophisticated Squamous cell carcinoma.
Role of Twist in head and neck carcinoma with lymph node metastasis.
TLDR
FindPatterns analysis suggested that the transcription factor Twist, as a basic helix-loop-helix (bHLH) protein, might regulate CXCR4 and CCR7 expression in squamous cell carcinomas, which in turn might be associated with lymph node metastasis.
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
TLDR
Stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation that is pivotal for the transformation into an aggressive breast cancer phenotype.
Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma.
  • R. Niu, L. Zhang, +4 authors X. Hao
  • Biology, Medicine
    Journal of experimental & clinical cancer research : CR
  • 2007
TLDR
It is found that Twist mRNA and protein were both increased in HCC as compared to non-cancerous tissues and Twist expression may become a potential novel prognostic factor for the disease survival of HCC.
Identification of Novel Tumor Markers in Prostate, Colon and Breast Cancer by Unbiased Methylation Profiling
DNA hypermethylation is a common epigenetic abnormality in cancer and may serve as a useful marker to clone cancer-related genes as well as a marker of clinical disease activity. To identify CpG…
Expression and significance of TWIST basic helix‐loop‐helix protein over‐expression in gastric cancer
TLDR
Its up‐regulation was associated with the neoplastic transformation and subsequent development of gastric cancer, and TWIST maybe a useful prognostic marker and target for Gastric cancer therapy.
Twist, a novel oncogene, is upregulated in pancreatic cancer: Clinical implication of Twist expression in pancreatic juice
TLDR
The results suggest that Twist is involved in tumor progression of pancreatic cancer and that measurement of Twist in pancreatic juice may be useful to differentiate pancreaticcancer from nonmalignant neoplasms such as IPMN.
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