TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene.

@article{ShemeshDarvish2018TV1380AC,
  title={TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene.},
  author={Liron Shemesh-Darvish and D. Shinar and H. Hallak and A. Gross and M. Rosenstock},
  journal={Drug and alcohol dependence},
  year={2018},
  volume={188},
  pages={
          295-303
        }
}
BACKGROUND TV-1380 is a rationally mutated, human BChE fused to human serum albumin that has high hydrolytic enzymatic activity against cocaine and as well as an extended elimination half-life. OBJECTIVE The present studies examined the safety of TV-1380 and its protective effect when given to monkeys alone or concomitantly with cocaine and ethanol. METHODS A set of studies was conducted in monkeys with TV-1380. The parameters tested included telemetric assessment of cardiovascular… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
An Engineered Cocaine Hydrolase Blunts and Reverses Cardiovascular Responses to Cocaine in Rats
  • Yang Gao, S. Brimijoin
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2004
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence.
Cocaine and alcohol interactions in humans: neuroendocrine effects and cocaethylene metabolism.
An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.
The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions
Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.
...
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3
4
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