TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

  title={TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice},
  author={Ana Filipa Nunes and Joana D Amaral and Adrian C Lo and Mar{\'i}a Blanco Fonseca and Ricardo J. S. Viana and Zsuzsanna Callaerts-Vegh and Rudi D’Hooge and Cec{\'i}lia Maria Pereira Rodrigues},
  journal={Molecular Neurobiology},
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. The endogenous bile acid tauroursodeoxycholic acid (TUDCA) is a strong neuroprotective agent in several experimental models of disease, including neuronal exposure to Aβ. Nevertheless, the therapeutic role of TUDCA in AD pathology has not yet been ascertained. Here we report that feeding APP… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 54 references

Alzheimer's disease: genes, proteins, and therapy.

Physiological reviews • 2001
View 7 Excerpts
Highly Influenced

Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2005
View 5 Excerpts
Highly Influenced

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 4 Excerpts
Highly Influenced

Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin

Y Ohki, T Higo, +7 authors T Iwatsubo
EMBO J 30:4815–4824 • 2011

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