TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

@article{Nunes2012TUDCAAB,
  title={TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice},
  author={Ana Filipa Nunes and Joana D Amaral and Adrian C Lo and Mar{\'i}a Blanco Fonseca and Ricardo J. S. Viana and Zsuzsanna Callaerts-Vegh and Rudi D’Hooge and Cec{\'i}lia Maria Pereira Rodrigues},
  journal={Molecular Neurobiology},
  year={2012},
  volume={45},
  pages={440-454}
}
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. The endogenous bile acid tauroursodeoxycholic acid (TUDCA) is a strong neuroprotective agent in several experimental models of disease, including neuronal exposure to Aβ. Nevertheless, the therapeutic role of TUDCA in AD pathology has not yet been ascertained. Here we report that feeding APP… CONTINUE READING

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