TTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation

@article{Yang1991TTXsensitiveAT,
  title={TTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation},
  author={Jane Yang and J. Sladky and R. Kallen and R. Barchi},
  journal={Neuron},
  year={1991},
  volume={7},
  pages={421-427}
}
The expression of mRNA encoding the TTX-sensitive (SkM1) and TTX-insensitive (SkM2) voltage-dependent sodium channels in adult skeletal muscle is independently regulated. In normal skeletal muscle, only the SkM1 message is expressed and the level varies with muscle fiber type. After surgical denervation, the steady-state SkM1 mRNA level declines transiently, but returns to control levels within 5 days. Expression of SkM2 transcripts is markedly activated, reaching a peak 3 days after axotomy… Expand
Altered Gene Expression in Steroid-Treated Denervated Muscle
TLDR
To better understand the marked upregulation of SkM2 in steroid-denervated muscle, changes in myogenin and glucocorticoid receptor mRNA levels cannot account for the upregulation. Expand
Sodium Channel mRNAs at the Neuromuscular Junction: Distinct Patterns of Accumulation and Effects of Muscle Activity
TLDR
Factors, probably derived from the nerve, lead to the increased concentration of VGSC mRNAs at the NMJ, and the expression of NaV1.5 mRNA is downregulated by muscle activity, both at theNMJ and away from it. Expand
Expression of the sodium channel β 1 subunit in rat skeletal muscle is selectively associated with the tetrodotoxin-sensitive α subunit isoform
Abstract Transcripts homologous to the rat brain sodium channel β subunit ( β 1 ) are prominently expressed in both innervated and denervated adult skeletal muscle and in heart, but not in neonatalExpand
Sodium Channel NaV1.5 Expression is Enhanced in Cultured Adult Rat Skeletal Muscle Fibers
TLDR
The FDB model is a useful tool to study the effects of denervation in adult muscle fibers in vitro and the expression of sodium channels, and the involvement of β subunits in the regulation of sodium current and fiber excitability. Expand
Differential modulation of TTX-sensitive and TTX-resistant Na+ channels in spinal cord astrocytes following activation of protein kinase C
  • C. Thio, H. Sontheimer
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
TLDR
Activation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) exhibited different effects on TTX-S andTTX-R Na+ currents, suggesting that PKC phosphorylation may have activated formerly quiescent Na+ channels. Expand
Na+ channel and acetylcholine receptor changes in muscle at sites distant from burns do not simulate denervation.
TLDR
The unaltered levels of transcripts of myogenin, SkM2 of Na+ channels and gamma-subunit of AChR, confirm that there is no denervation-like prejunctional (nerve-related) component to explain the muscle weakness or the upregulation of A ChRs at sites distant from burns. Expand
Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression.
TLDR
The observed increase in sodium current density may reduce the resistance to fatigue of antigravity muscle fibres, an effect that may contribute to muscle impairment in humans after space flight or after long immobilization. Expand
Cell-specific differential expression of Na(+)-channel beta 1-subunit mRNA in the olfactory system during postnatal development and after denervation
TLDR
In situ hybridization shows that Na beta 1 mRNA expression is upregulated developmentally, but with different time courses in mitral, tufted, and pyramidal cells, and suggest that the expression of Nabeta 1 is regulated independently of Na alpha mRNAs via cell-specific and pathway-specific mechanisms. Expand
Sodium influx during action potential in innervated and denervated rat skeletal muscles
TLDR
The results suggest that the depolarization, mainly due to the increase in PNa /PK ratio, increases Na+ inactivation and consequently reduces peak gNa, in spite of the absolute increment in resting TTX‐sensitive PNa. Expand
Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5
TLDR
An altered expression of voltage-gated sodium channel isoforms as a novel mechanism to explain the occurrence of fibrillation potentials following skeletal muscle denervation is proposed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle
TLDR
It is suggested that SkM2 is a TTX-insensitive sodium channel expressed in both skeletal and cardiac muscle, similar to other recently cloned sodium channels from rat skeletal muscle. Expand
SkM2, a Na+ channel cDNA clone from denervated skeletal muscle, encodes a tetrodotoxin-insensitive Na+ channel.
TLDR
Examination of the functional properties of SkM2 Na+ channels after expression in Xenopus oocytes indicates that they are the TTX-insensitive Na-channel channels found in denervated or developing skeletal muscle and are identical to the TTx-inssensitive Na- channels from heart. Expand
Two subtypes of sodium channel with tetrodotoxin sensitivity and insensitivity detected in denervated mammalian skeletal muscle
TLDR
The detection of Na channels with low-affinity binding of STX and TTX is reported, accounting for 50-60% of the Na channels in rat hindlimb muscle 4-5 days after denervation. Expand
Acetylcholine receptors and sodium channels in denervated and botulinum‐toxin‐treated adult rat muscle.
TLDR
It was concluded that neuromuscular blockade with BoTX is equivalent to denervation in its effects on synthesis of ACh receptors and numbers of Na channels are more stable than A Ch receptors but may also be modulated by neuromUScular activity. Expand
Functional differences between two classes of sodium channels in developing rat skeletal muscle.
TLDR
The lower conductance of TTX-resistant channels provides insight into the relationship between the TTX binding site and the external mouth of the sodium channel. Expand
Muscle insensitivity to tetrodotoxin: induction by alpha-bungarotoxin and removal by submechanical threshold stimulation.
TLDR
Findings indicate that in addition to sarcolemmal sensitivity to acetylcholine, sensitivity of the sodium conductance mechanism to TTX is also directly influenced by muscle activity independent of contraction. Expand
Characterization of thyroid hormone effects on Na channel synthesis in cultured skeletal myotubes: role of Ca2+.
TLDR
Thyroid hormones appear to regulate Na channels in cultured myotubes by two opposing mechanisms; direct stimulation of Na channel synthesis, and indirect decrease in synthesis mediated by an increase in cytosolic Ca2+. Expand
Na+ channels with high and low affinity tetrodotoxin binding sites in the mammalian skeletal muscle cell. Difference in functional properties and sequential appearance during rat skeletal myogenesis.
TLDR
It is suggested that neuronal factors are not required for the synthesis of structures with high affinity binding sites for tetrodotoxin in the rat muscle and that they are only involved for the maturation of these structures from a nonfunctional to a functional form. Expand
Primary structure and functional expression of a mammalian skeletal muscle sodium channel
TLDR
The isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle is described, and northern blot analysis indicates that the 8.5 kb microI transcript is preferentially expressed in skeletal muscle. Expand
Neural regulation of [3H]saxitoxin binding site numbers in rat neonatal muscle.
TLDR
It was concluded that the neural influence on incorporation of Na+ channels into membranes of neonatal muscle is, at least in part, mediated by neuromuscular activity. Expand
...
1
2
3
4
5
...