TTP Specifically Regulates the Internalization of the Transferrin Receptor

Abstract

Different plasma membrane receptors are internalized through saturable/noncompetitive pathways, suggesting cargo-specific regulation. Here, we report that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). TTP interacts with endocytic proteins, including clathrin, dynamin, and the TfR, and… (More)
DOI: 10.1016/j.cell.2005.10.021

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